Everything about Trichloroacetic Acid totally explained
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Trichloroacetic acid (also known as
trichloroethanoic acid) is an analogue of
acetic acid in which the three
hydrogen atoms of the
methyl group have all been replaced by
chlorine atoms.
It is prepared by the reaction of chlorine with acetic acid in the presence of a suitable
catalyst.
» CH
3COOH + 3Cl
2 → CCl
3COOH + 3HCl
It is widely used in
biochemistry for the precipitation of macromolecules such as
proteins,
DNA and
RNA. Its
sodium salt is used as a
weedkiller. Solutions containing trichloroacetic acid as an ingredient are used for tattoo removal and the treatment of
warts, including
genital warts. It can kill normal cells as well. It is considered safe for use for this purpose during pregnancy.
Salts of trichloroacetic acid are called
trichloroacetates. Reduction of trichloroacetic acid results in
dichloroacetic acid, a pharmacologically active compound that shows promise for the treatment of
cancer.
History
The discovery of trichloroacetic acid by
Jean-Baptiste Dumas in 1840 delivered a striking example to the slowly evolving theory of organic radicals and valences. The theory was contrary to the beliefs of
Jöns Jakob Berzelius, starting a long dispute between Dumas and Berzelius.
Further Information
Get more info on 'Trichloroacetic Acid'.
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